| Most Games | ||
| 76 | Sid Monge (LHP) | 1979 |
| 72 | Paul Shuey (RHP) | 1999 |
| 72 | Mike Jackson (RHP) | 1999 |
| 72 | Steve Olin (RHP) | 1992 | Most Games Started |
| 44 | George Uhle | 1923 | Most Complete Games |
| 36 | Bob Feller | 1946 | Most Innings Pitched |
| 371 | Bob Feller | 1946 | Most Wins |
| 23 | Vean Gregg (LHP) | 1911 |
| 31 | Jim Bagby, Sr. (RHP) | 1920 | Most Consecutive Wins |
| 15 | Gaylord Perry | 1974 |
| 15 | Johnny Allen | 1937 | Most Relief Wins |
| 12 | Dan Spillner | 1982 |
| 12 | Sid Monge | 1979 | Most Loses |
| 22 | Pete Dowling | 1901 | Most Consecutive Loses |
| 13 | Guy Morton | 1914 | Most Relief Loses |
| 10 | Doug Jones | 1989 |
| 10 | Dan Spillner | 1982 |
| 10 | Jim Kern | 1977 - 78 | Most Saves |
| 21 | Dave LaRoche (LHP) | 1976 |
| 46 | Jose Mesa (RHP) | 1995 | Most Consecutive Saves |
| 38 | Jose Mesa | 1995 (MLB Record) | Most Games Finished |
| 64 | Doug Jones | 1990 | Most Shutouts |
| 10 | Bob Lemon | 1948 |
| 10 | Bob Feller | 1946 | Most Shutout Loses |
| 7 | Bob Feller | 1946 | Most Consecutive Shutouts |
| 4 | Luis Tiant | 1968 | Most Consecutive Hitless Innings |
| 22 1/3 | Dennis Eckersley | 1977 | Most Strikeouts |
| 325 | Sam McDowell (LHP) | 1965 |
| 348 | Bob Feller (RHP) | 1946 | Most Base on Balls |
| 208 | Bob Feller | 1936 (A.L. Record) |
All records and history taken from the Cleveland Indians media guide.
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